In 1848, a railroad worker named Phineas Gage suffered an accident that was to secure him a place in neuroscience lore. While constructing a new railway line, a mistimed explosion propelled an iron bar into the base of his skull, where it passed behind his left eye before exiting through the top of his head. Gage survived the accident, but those who knew him reported significant changes in his personality and behaviour.
Gage’s ability to make decisions was particularly impaired by his injury. Decision-making involves weighing up the costs and benefits associated with alternative courses of action. It entails looking into the future to decide whether an anticipated reward will justify the effort or expense necessary to obtain it. This process is dependent on a region of the brain called the prefrontal cortex, the area that sustained the most damage in Phineas Gage.
Read more from eLife Digest on Medium | January 15th, 2016: https://medium.com/brains-and-behaviour/time-to-make-a-decision-d8ec0b8c4d3f#.drcxbd7w4