May 14, 2018
"Alzheimer’s disease develops when proteins in the brain form abnormal tangles, and a key player is tau protein, which normally stabilizes the cytoskeleton of neurons.
Though the structure of tau tangles is known, scientists have understood less about how normal tau interacts with the structural components of the cytoskeleton, the so-called microtubules.
A team led by Eva Nogales, a UC Berkeley professor of molecular and cell biology, senior faculty scientist at Berkeley Lab and Howard Hughes Medical Institute investigator, has now determined the detailed structure of the tau protein when bound to microtubules."
Read more from Berkeley News: https://news.berkeley.edu/2018/05/14/new-structure-of-tau-protein-a-key-...